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Has been used to ameliorate or prevent sequelae associated with cerebral ischemia during neurosurgical procedures† [Non attivato-label] that require long periods of cerebral hypoxia.
Studies Per laboratory animals have shown that barbiturates cause reduction Sopra the tone and contractility of the uterus, ureters, and urinary bladder. However, concentrations of the drugs required to produce this effect in humans are not reached with sedative-hypnotic doses.
Avoiding tissue extravasation Sopra this process is essential as it has been known to cause tissue necrosis. Clinicians should avoid rapid IV injection as it may result Durante respiratory depression, hypotension, and bronchospasm, among other adverse effects.
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However, the use of barbiturates as sedatives Con the postoperative surgical period and as adjuncts to cancer chemotherapy is well established.
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The sodium salt occurs as a white, slightly bitter powder which is freely soluble Per water and alcohol but practically insoluble Con benzene and ether.
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Use with caution; should not be used Per mezzo di patients with marked hepatic impairment, including patients with premonitory signs of hepatic coma.
As with any potent pharmaceutical agent, a thorough understanding of its uses, effects, and risks is essential for healthcare providers to deliver safe and effective patient care.